Comparisons

See how Neuro-Free® (PVC) stacks up against cord blood, amnion, and bone marrow therapies on comfort, flexibility, cell count, and more.

Basic Advanced

Neuro-Free (PVC)

Cord Blood

Amnion

Bone Marrow

SVF

Cultured Expanded

Basic comparison table for Neuro-Free PVC, Cord Blood, Amnion, Bone Marrow, SVF, and Cultured Expanded products.
Comparison Topic	Neuro-Free (PVC)	Cord Blood	Amnion	Bone Marrow	SVF	Cultured Expanded
Patented	Patented Patented in 20+ countries Yes, Patented Process	Patented Standard blood banking No Patented Process	Patented Standard tissue processing No Patented Process	Patented Standard marrow aspiration No Patented Process	Patented Standard centrifuge steps No Patented Process	Patented Process varies by clinic No Patented Process
Source & Collection

Harvest locations	Harvest locations Stomach, low back, or thighs More Comfortable	Harvest locations Collected at birth from cord blood Limited to time of birth	Harvest locations Harvested from placenta if whole placenta is collected Different types of products Limited	Harvest locations Pelvis / femur	Harvest locations Stomach, low back, or thighs	Harvest locations Bone, adipose/fat tissue, or umbilical cord
Accepted donors	Accepted donors Parents, children, siblings, recipient Most Flexible	Accepted donors Parent or unknown donor possible with HLA testing	Accepted donors Unknown donors	Accepted donors Same recipient as donor	Accepted donors Same recipient as donor	Accepted donors Varies by source tissue; another patient tissue may be harvested aseptically
Collection limitations & concerns	Collection limitations & concerns Requires harvest and lab delivery	Collection limitations & concerns Limited counts; limited available product; donor matching may be needed Limited Possible Donors	Collection limitations & concerns Possible E. coli contamination	Collection limitations & concerns Limited collections over lifetime; bleeding, pain, or infection risks noted Most Risk	Collection limitations & concerns Designed for use during the same surgical procedure Surgery-Only Use	Collection limitations & concerns Marker drift, contamination risk, and only available abroad Only Available Abroad
Processing & Storage

Stored frozen	Stored frozen Yes	Stored frozen Yes	Stored frozen Yes	Stored frozen Typically not stored	Stored frozen No; intended for same-time surgical use	Stored frozen Yes
Cell count reporting to patient	Cell count reporting to patient Yes; total nucleated cells, total cells, and live cell counts recorded and provided	Cell count reporting to patient CFU testing is done	Cell count reporting to patient No	Cell count reporting to patient No	Cell count reporting to patient No	Cell count reporting to patient Cells are counted, washed, and reseeded until target counts are reached
Cell Profile

Cell Counts	Cell Counts 30 to 90 million stem cells Most Precise Treatment	Cell Counts 50,000-100,000 stem cells Low Stem Cell Count	Cell Counts No stem cells after processing	Cell Counts Estimated cell counts typically 35,000-50,000 stem cells depending on process	Cell Counts About 50,000 stem cells per 50 cc of fluid	Cell Counts Typically 60,000-100,000 stem cells
Cells retained after processing	Cells retained after processing Yes; PVC as a live cell product	Cells retained after processing Yes	Cells retained after processing Lyophilization and dehydration destroy all cells	Cells retained after processing Yes, but very low MSC portion	Cells retained after processing Yes, but very low MSC portion	Cells retained after processing Yes, numbers depend on process
Nucleated cell counts	Nucleated cell counts Provided for each patient and treatment specifically	Nucleated cell counts Estimated cell counts unless requested	Nucleated cell counts Estimated cell counts	Nucleated cell counts Estimated cell counts	Nucleated cell counts Estimated cell counts	Nucleated cell counts Numbers depend on process
Intended Use

Intended use	Intended use Increase blood concentrations in circulation	Intended use Increase blood concentrations in circulation	Intended use Skin treatments or wounds	Intended use Injections in joints, muscles or tendons	Intended use Orthopedic injections	Intended use Increase blood concentrations in circulation

Advanced comparison table for Neuro-Free PVC, Cord Blood, Amnion, Bone Marrow, SVF, and Cultured Expanded products.
Comparison Topic	Neuro-Free (PVC)	Cord Blood	Amnion	Bone Marrow	SVF	Cultured Expanded
Patented	Patented Patented in 20+ countries Yes, Patented Process	Patented Standard blood banking No Patented Process	Patented Standard tissue processing No Patented Process	Patented Standard marrow aspiration No Patented Process	Patented Standard centrifuge steps No Patented Process	Patented Process varies by clinic No Patented Process
Source & Collection

Harvest locations	Harvest locations Stomach, low back, or thighs More Comfortable	Harvest locations Collected at birth from cord blood Limited to time of birth	Harvest locations Harvested from placenta if whole placenta is collected Different types of products Limited	Harvest locations Pelvis / femur	Harvest locations Stomach, low back, or thighs	Harvest locations Bone, adipose/fat tissue, or umbilical cord
Accepted donors	Accepted donors Parents, children, siblings, recipient Most Flexible	Accepted donors Parent or unknown donor possible with HLA testing	Accepted donors Unknown donors	Accepted donors Same recipient as donor	Accepted donors Same recipient as donor	Accepted donors Varies by source tissue; another patient tissue may be harvested aseptically
Collection limitations & concerns	Collection limitations & concerns Requires harvest and lab delivery	Collection limitations & concerns Limited counts; limited available product; donor matching may be needed Limited Possible Donors	Collection limitations & concerns Possible E. coli contamination	Collection limitations & concerns Limited collections over lifetime; bleeding, pain, or infection risks noted Most Risk	Collection limitations & concerns Designed for use during the same surgical procedure Surgery-Only Use	Collection limitations & concerns Marker drift, contamination risk, and only available abroad Only Available Abroad
Harvest / collection method	Harvest / collection method Fluid is harvested, then the entire harvest is delivered to the lab	Harvest / collection method Fluid is centrifuged, the bottom 2-5 mL is retained, and DMSO is added	Harvest / collection method Placenta tissue is dissected, washed, separated, and then preserved	Harvest / collection method Liquid or pieces of bone marrow are aspirated and then concentrated	Harvest / collection method Liposuction harvest is centrifuged and the pellet is isolated	Harvest / collection method Source tissue is plated, non-adherent cells are removed, and MSCs are expanded in media
Typical collection size / time	Typical collection size / time Entire harvest is processed through the lab	Typical collection size / time Typical total harvest is about 60 cc (mL) / 2 oz	Typical collection size / time Whole placenta harvest when used as source material	Typical collection size / time Harvest takes about 30 minutes	Typical collection size / time About 50 cc of fluid is commonly referenced	Typical collection size / time Expansion depends on repeated passaging cycles
Processing & Storage

Stored frozen	Stored frozen Yes	Stored frozen Yes	Stored frozen Yes	Stored frozen Typically not stored	Stored frozen No; intended for same-time surgical use	Stored frozen Yes
Cell count reporting to patient	Cell count reporting to patient Yes; total nucleated cells, total cells, and live cell counts recorded and provided	Cell count reporting to patient CFU testing is done	Cell count reporting to patient No	Cell count reporting to patient No	Cell count reporting to patient No	Cell count reporting to patient Cells are counted, washed, and reseeded until target counts are reached
Processing summary	Processing summary Patented development in an FDA registered lab with recorded counts	Processing summary Blood banking process centered on centrifugation and cryostorage	Processing summary Decellularization, crosslinking, preservation, and sterilization	Processing summary Typically concentrated before application	Processing summary Centrifuge separation with the pellet considered the final cell fraction	Processing summary MSCs are expanded in rich media with repeated passaging
Storage method	Storage method Labeled and stored in a -80 bio-freezer until requested	Storage method Rate-controlled freezer, then transferred to -80 storage	Storage method Lyophilization, dehydration, or cryopreservation may be used	Storage method Typically not stored	Storage method Not designed for storage; same surgical setting use	Storage method Stored in 10% DMSO in -80 bio-freezers
Storage timeline / access	Storage timeline / access Pulled upon request and delivered to the desired clinic	Storage timeline / access Typically lasts 10-15 years depending on processing	Storage timeline / access Depends on the preservation and sterilization approach	Storage timeline / access Usually not stored	Storage timeline / access Intended for same-time surgical use	Storage timeline / access Stored after expansion and thawed when needed
Quality / safety notes	Quality / safety notes Counts are recorded and provided to the patient	Quality / safety notes CFU typically determines product value	Quality / safety notes Sterilization can alter biological and physical properties	Quality / safety notes Rare bleeding, pain, or infection risks are recorded	Quality / safety notes Harvest pressure can reduce average viability	Quality / safety notes Can only be screened for known cancer cells; contamination remains a concern
Cell Profile

Cell Counts	Cell Counts 30 to 90 million stem cells Most Precise Treatment	Cell Counts 50,000-100,000 stem cells Low Stem Cell Count	Cell Counts No stem cells after processing	Cell Counts Estimated cell counts typically 35,000-50,000 stem cells depending on process	Cell Counts About 50,000 stem cells per 50 cc of fluid	Cell Counts Typically 60,000-100,000 stem cells
Cells retained after processing	Cells retained after processing Yes; PVC as a live cell product	Cells retained after processing Yes	Cells retained after processing Lyophilization and dehydration destroy all cells	Cells retained after processing Yes, but very low MSC portion	Cells retained after processing Yes, but very low MSC portion	Cells retained after processing Yes, numbers depend on process
Nucleated cell counts	Nucleated cell counts Provided for each patient and treatment specifically	Nucleated cell counts Estimated cell counts unless requested	Nucleated cell counts Estimated cell counts	Nucleated cell counts Estimated cell counts	Nucleated cell counts Estimated cell counts	Nucleated cell counts Numbers depend on process
Typical live cell viability	Typical live cell viability Typical live cell counts (CFU) are 95-100%	Typical live cell viability CFU testing is done for live cell counts	Typical live cell viability No cells remain after processing	Typical live cell viability Older patients yield lower live numbers	Typical live cell viability Average viability is around 56%	Typical live cell viability Most effective through early growth cycles and declines with passaging
Stem cell concentration / profile	Stem cell concentration / profile Total stem cell counts typically 30-90 million	Stem cell concentration / profile Typical stem cell counts are 50,000-100,000	Stem cell concentration / profile No cells at all remain in the final processed product	Stem cell concentration / profile Estimated cell counts typically 35,000-50,000 stem cells depending on process	Stem cell concentration / profile Stem cells are represented by the pellet fraction after centrifuge	Stem cell concentration / profile Typically 60,000-100,000 stem cells
Typical total nucleated cells	Typical total nucleated cells Total nucleated cell counts are typically around 8.5 billion	Typical total nucleated cells Typical total nucleated cell counts are around 470,000	Typical total nucleated cells No cells remain after processing	Typical total nucleated cells Typical total cell concentrations are around 532,000	Typical total nucleated cells Document emphasizes total cell yield rather than a separate TNC count	Typical total nucleated cells Counts are expanded to the desired level outside the body
Intended Use

Intended use	Intended use Increase blood concentrations in circulation	Intended use Increase blood concentrations in circulation	Intended use Skin treatments or wounds	Intended use Injections in joints, muscles or tendons	Intended use Orthopedic injections	Intended use Increase blood concentrations in circulation
Clinical Use & Availability

Originally developed / primary role	Originally developed / primary role Built around the perivascular fraction where MSCs reside	Originally developed / primary role Initially developed from blood banking for leukemia	Originally developed / primary role Processed for wound coverage and graft-style applications	Originally developed / primary role Initially used as a diagnostic tool for leukemia or lymphoma	Originally developed / primary role Origin of the current stem cell market	Originally developed / primary role Designed to grow stem cells outside the body to increase numbers
Designed for injections	Designed for injections Yes; designed for injections	Designed for injections Not positioned in the document as a routine injection product	Designed for injections Not designed for injections	Designed for injections Typically used for joint or orthopedic injections	Designed for injections Yes, but only in same-time surgical settings	Designed for injections Not offered in the U.S.; only abroad
Designed for infusions	Designed for infusions Yes; designed for infusions	Designed for infusions Not described as designed for infusions	Designed for infusions Not designed for infusions	Designed for infusions Not designed to be infused	Designed for infusions Not designed to be infused	Designed for infusions Not offered in U.S. facilities; sought abroad
Availability & coverage notes	Availability & coverage notes Delivered in U.S. physician-led settings	Availability & coverage notes Based on blood banking guidelines and stored under AABB guidance	Availability & coverage notes Only fresh frozen retains original protein and growth factor concentrations	Availability & coverage notes Can be covered by insurance	Availability & coverage notes Used during the same surgical procedure, not stored or shipped for later use	Availability & coverage notes Not available in the U.S.; families travel abroad

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Cells Prepared by BrioMD Labs

Parent-donated cells are processed in BrioMD Labs' FDA registered lab.

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The therapy follows rigorous protocols, is administered in a controlled setting, and complies with FDA guidelines outlined in 21 CFR 1271.10, which define oversight under section 361 of the PHS Act and 21 CFR Part 1271.